SrasV1, Main, Exploration, bibRecord, 004447

Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

Identifieur interne : 004447 ( Main/Exploration ); précédent : 004446; suivant : 004448

Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

Auteurs : Vera S. F. Chan [Hong Kong] ; Kelvin Y. K. Chan [Hong Kong] ; YONGXIONG CHEN [Hong Kong] ; Leo L. M. Poon [Hong Kong] ; Annie N. Y. Cheung [Hong Kong] ; BOJIAN ZHENG [Hong Kong] ; Kwok-Hung Chan [Hong Kong] ; William Mak [Hong Kong] ; Hextan Y. S. Ngan [Hong Kong] ; XIAONING XU [Royaume-Uni] ; Gavin Screaton [Royaume-Uni] ; Paul K. H. Tam [Hong Kong] ; Jonathan M. Austyn [Royaume-Uni] ; Li-Chong Chan [Hong Kong] ; Shea-Ping Yip [Hong Kong] ; Malik Peiris [Hong Kong] ; Ui-Soon Khoo [Hong Kong] ; Chen-Lung S. Lin [Hong Kong]

Source :

Nature genetics [ 1061-4036 ] ; 2006.

RBID : Pascal:06-0214013

Descripteurs français

KwdFr :
- Animaux, Cellules CHO (virologie), Cellules Vero (virologie), Cricetinae, Cricetulus, Données de séquences moléculaires, Homozygote, Hong Kong (épidémiologie), Humains, Intestin grêle (physiologie), Lectines de type C (génétique), Lectines de type C (métabolisme), Molécules d'adhérence cellulaire (génétique), Molécules d'adhérence cellulaire (métabolisme), Poumon (physiologie), Poumon (virologie), Proteasome endopeptidase complex (métabolisme), Prédisposition génétique à une maladie, Récepteurs de surface cellulaire (génétique), Récepteurs de surface cellulaire (métabolisme), Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (épidémiologie), Séquences répétées en tandem, Virus du SRAS (métabolisme), Virus du SRAS (pathogénicité), Études de cohortes.
MESH :
- génétique : Lectines de type C, Molécules d'adhérence cellulaire, Récepteurs de surface cellulaire, Syndrome respiratoire aigu sévère.
- métabolisme : Lectines de type C, Molécules d'adhérence cellulaire, Proteasome endopeptidase complex, Récepteurs de surface cellulaire, Virus du SRAS.
- pathogénicité : Virus du SRAS.
- physiologie : Intestin grêle, Poumon.
- virologie : Cellules CHO, Cellules Vero, Poumon.
- épidémiologie : Hong Kong, Syndrome respiratoire aigu sévère.
Pascal (Inist)
- Animaux, Cricetinae, Cricetulus, Données de séquences moléculaires, Homozygote, Humains, Prédisposition génétique à une maladie, Syndrome respiratoire aigu sévère, Coronavirus, Séquences répétées en tandem, Études de cohortes.
Wicri :
- geographic : Hong Kong.

English descriptors

KwdEn :
- Animals, CHO Cells (virology), Cell Adhesion Molecules (genetics), Cell Adhesion Molecules (metabolism), Chlorocebus aethiops, Cohort Studies, Coronavirus, Cricetinae, Cricetulus, Genetic Predisposition to Disease, Homozygote, Hong Kong (epidemiology), Humans, Intestine, Small (physiology), Lectins, C-Type (genetics), Lectins, C-Type (metabolism), Lung (physiology), Lung (virology), Molecular Sequence Data, Proteasome Endopeptidase Complex (metabolism), Receptors, Cell Surface (genetics), Receptors, Cell Surface (metabolism), SARS Virus (metabolism), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (genetics), Severe acute respiratory syndrome, Tandem Repeat Sequences, Vero Cells (virology).
MESH :
- chemical , genetics : Cell Adhesion Molecules, Lectins, C-Type, Receptors, Cell Surface.
- chemical , metabolism : Cell Adhesion Molecules, Lectins, C-Type, Proteasome Endopeptidase Complex, Receptors, Cell Surface.
- geographic , epidemiology : Hong Kong.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : Severe Acute Respiratory Syndrome.
- metabolism : SARS Virus.
- pathogenicity : SARS Virus.
- physiology : Intestine, Small, Lung.
- virology : CHO Cells, Lung, Vero Cells.
- Animals, Chlorocebus aethiops, Cohort Studies, Cricetinae, Cricetulus, Genetic Predisposition to Disease, Homozygote, Humans, Molecular Sequence Data, Tandem Repeat Sequences.

Abstract

Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. L-SIGN is expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for L-SIGN, cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection. Thus, homozygosity for L-SIGN plays a protective role during SARS infection.

Affiliations:

Le document en format XML

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</affiliation>
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<author><name sortKey="Chan, Li Chong" sort="Chan, Li Chong" uniqKey="Chan L" first="Li-Chong" last="Chan">Li-Chong Chan</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pathology, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road</s1>
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<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yip, Shea Ping" sort="Yip, Shea Ping" uniqKey="Yip S" first="Shea-Ping" last="Yip">Shea-Ping Yip</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Health Technology and Informatics, The Hong Kong Polytechnic University</s1>
<s3>HKG</s3>
<sZ>15 aut.</sZ>
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<country>Hong Kong</country>
<wicri:noRegion>Department of Health Technology and Informatics, The Hong Kong Polytechnic University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
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<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
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<country>Hong Kong</country>
<wicri:noRegion>Department of Microbiology, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khoo, Ui Soon" sort="Khoo, Ui Soon" uniqKey="Khoo U" first="Ui-Soon" last="Khoo">Ui-Soon Khoo</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pathology, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road</s1>
<s3>HKG</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Chen Lung S" sort="Lin, Chen Lung S" uniqKey="Lin C" first="Chen-Lung S." last="Lin">Chen-Lung S. Lin</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgery, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>18 aut.</sZ>
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<country>Hong Kong</country>
<wicri:noRegion>Department of Surgery, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
<imprint><date when="2006">2006</date>
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<term>CHO Cells (virology)</term>
<term>Cell Adhesion Molecules (genetics)</term>
<term>Cell Adhesion Molecules (metabolism)</term>
<term>Chlorocebus aethiops</term>
<term>Cohort Studies</term>
<term>Coronavirus</term>
<term>Cricetinae</term>
<term>Cricetulus</term>
<term>Genetic Predisposition to Disease</term>
<term>Homozygote</term>
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<term>Intestine, Small (physiology)</term>
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<term>Lectins, C-Type (metabolism)</term>
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<term>Lung (virology)</term>
<term>Molecular Sequence Data</term>
<term>Proteasome Endopeptidase Complex (metabolism)</term>
<term>Receptors, Cell Surface (genetics)</term>
<term>Receptors, Cell Surface (metabolism)</term>
<term>SARS Virus (metabolism)</term>
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<term>Humains</term>
<term>Intestin grêle (physiologie)</term>
<term>Lectines de type C (génétique)</term>
<term>Lectines de type C (métabolisme)</term>
<term>Molécules d'adhérence cellulaire (génétique)</term>
<term>Molécules d'adhérence cellulaire (métabolisme)</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. L-SIGN is expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for L-SIGN, cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection. Thus, homozygosity for L-SIGN plays a protective role during SARS infection.</div>
</front>
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<name sortKey="Mak, William" sort="Mak, William" uniqKey="Mak W" first="William" last="Mak">William Mak</name>
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<name sortKey="Yip, Shea Ping" sort="Yip, Shea Ping" uniqKey="Yip S" first="Shea-Ping" last="Yip">Shea-Ping Yip</name>
<name sortKey="Yongxiong Chen" sort="Yongxiong Chen" uniqKey="Yongxiong Chen" last="Yongxiong Chen">YONGXIONG CHEN</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Xiaoning Xu" sort="Xiaoning Xu" uniqKey="Xiaoning Xu" last="Xiaoning Xu">XIAONING XU</name>
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<name sortKey="Austyn, Jonathan M" sort="Austyn, Jonathan M" uniqKey="Austyn J" first="Jonathan M." last="Austyn">Jonathan M. Austyn</name>
<name sortKey="Screaton, Gavin" sort="Screaton, Gavin" uniqKey="Screaton G" first="Gavin" last="Screaton">Gavin Screaton</name>
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Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

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